Postmark helps deliver and track transactional emails for web applications. In a nutshell, the service replaces SMTP (or sendmail) with a far more reliable, scalable and care-free environment. In addition, you can track statistics for number of emails sent, bounces and spam complaints.
To get started, you need a couple things first.
Sender signatures are needed in order to verify that, well, you really own the mailbox, and that you are not a spammer (yes, we hate spam too). You must have a sender signature for each from address used in your application.
Servers are just logical groups for the emails sent through Postmark. In general, you should create one server for each application you have, so that you have a better overview on the statistics.